Health and human services (HHS) organizations are implementing big changes, driven by the COVID-19 pandemic. There has been a rapid shift to telemedicine and other digital services. In addition, urgent public health needs and spiraling demand for safety net programs are accelerating efforts around data sharing, analytics, artificial intelligence, machine learning and other data-related technologies. This report explores the trends and technologies that are reshaping HHS today while promising long-term improvement of efficiencies and outcomes.