Spurred on by a perfect storm of program silos, regulatory burdens, the emergence of affordable AI, increasing cyber security risks and aging and unsustainable IT costs, the US Federal Government over the past two years has put significant resources and leadership towards modernizing government to generate better results for US citizens. This paper provides government with guidance on the first priority of CAP Goal 1, to “Enhance Mission Effectiveness,” based on IBM's deep and varied experience supporting modernization projects.